gfrα2 (R&D Systems)
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gfrα2
Gfrα2, supplied by R&D Systems, used in various techniques. Bioz Stars score: 94/100, based on 37 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/gfr%CE%B12/Human%2FMouse+GFR+alpha-2%2FGDNF+R+alpha-2+Antibody/pmc12859467-42-39-40
Average 94 stars, based on 37 article reviews
Gfrα2, supplied by R&D Systems, used in various techniques. Bioz Stars score: 94/100, based on 37 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/gfr%CE%B12/Human%2FMouse+GFR+alpha-2%2FGDNF+R+alpha-2+Antibody/pmc12859467-42-39-40
Average 94 stars, based on 37 article reviews
gfrα2 - by Bioz Stars,
2026-11
94/100 stars
Images
1) Product Images from "Peripheral immune response and axonal degeneration in the hind paw skin of mice with experimental autoimmune encephalomyelitis"
Article Title: Peripheral immune response and axonal degeneration in the hind paw skin of mice with experimental autoimmune encephalomyelitis
Journal: Neurobiology of Pain
doi: 10.1016/j.ynpai.2025.100207
Figure Legend Snippet: Temporal dynamics of GFRα2 fiber innervation. (A-F) Representative images of PGP9.5 staining in the dermal-epidermal junction in male (A-C) and female (D-F) mice at various disease time points. (G) Quantification of GFRα2+ fiber crossings per mm of dermal–epidermal length. **** p < 0.0001, Two-way ANOVA, Tukey’s multiple comparisons test.
Techniques Used: Staining
Related Articles
Cell Culture:Article Title: Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control. Article Snippet: The visceral (or autonomic) motor system controls involuntary functions that are regulated by the activity of smooth muscle fibers, cardiac muscle fibers and glands.. The two major divisions include the sympathetic and parasympathetic systems.. The control of both divisions is modulated by inputs from the hypothalamus to preganglionic neurons in the brainstem and spinal cord, which in turn determine the activity of the primary visceral motor neurons in autonomic ganglia. Control:Article Title: Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control. Article Snippet: The visceral (or autonomic) motor system controls involuntary functions that are regulated by the activity of smooth muscle fibers, cardiac muscle fibers and glands.. The two major divisions include the sympathetic and parasympathetic systems.. The control of both divisions is modulated by inputs from the hypothalamus to preganglionic neurons in the brainstem and spinal cord, which in turn determine the activity of the primary visceral motor neurons in autonomic ganglia. Recombinant:Article Title: Genetic interplay between transcription factor Pou4f1/Brn3a and neurotrophin receptor Ret in retinal ganglion cell type specification Article Snippet: .. GFRα2 1:100 Affinity Purification:Article Title: Genetic interplay between transcription factor Pou4f1/Brn3a and neurotrophin receptor Ret in retinal ganglion cell type specification Article Snippet: .. GFRα2 1:100 Article Title: Peripheral injury of pelvic visceral sensory nerves alters GFRα (GDNF family receptor alpha) localization in sensory and autonomic pathways of the sacral spinal cord Article Snippet: .. Transverse sections were then incubated on a shaker (48 h at room temperature) in affinity purified antisera raised against goat GFRα1 (1:400; R&D Systems, Minneapolis, MN, cat. no. AF560; RRID:AB_2110307), Incubation:Article Title: Peripheral injury of pelvic visceral sensory nerves alters GFRα (GDNF family receptor alpha) localization in sensory and autonomic pathways of the sacral spinal cord Article Snippet: .. Transverse sections were then incubated on a shaker (48 h at room temperature) in affinity purified antisera raised against goat GFRα1 (1:400; R&D Systems, Minneapolis, MN, cat. no. AF560; RRID:AB_2110307), Article Title: Angiotensin II receptor type 2 activation is required for cutaneous sensory hyperinnervation and hypersensitivity in a rat hind paw model of inflammatory pain Article Snippet: Sections were immersed for 1 hour at room temperature in blocking solution containing 1.5% normal goat or donkey serum (Jackson ImmunoResearch Laboratories, Inc. West Grove, PA), 0.5% porcine gelatin (Sigma, St. Louis, MO), 0.5% Triton X-100 (Sigma), and SuperBlock in PBS (Thermo Scientific, Rockford, IL). .. Sections were incubated overnight at room temperature with primary antibodies directed against PGP9.5 (rabbit IgG,1:1200, AbD Serotec, Raleigh, NC), CGRP (sheep polyclonal, 1:500, Enzo Life Sciences International, Inc., Plymouth Meeting, PA), langerin (goat polyclonal, 1:100, Santa Cruz Biotechnology Inc., Santa Cruz, CA), Immunohistochemistry:Article Title: GDNF availability determines enteric neuron number by controlling precursor proliferation. Article Snippet: Activated caspase 3 antibody (D175, Cell Signaling Technology, 1:100) staining was performed on 6 μm paraffin wax-embedded specimens. .. GFRα1 and Marker:Article Title: Angiotensin II receptor type 2 activation is required for cutaneous sensory hyperinnervation and hypersensitivity in a rat hind paw model of inflammatory pain Article Snippet: Sections were immersed for 1 hour at room temperature in blocking solution containing 1.5% normal goat or donkey serum (Jackson ImmunoResearch Laboratories, Inc. West Grove, PA), 0.5% porcine gelatin (Sigma, St. Louis, MO), 0.5% Triton X-100 (Sigma), and SuperBlock in PBS (Thermo Scientific, Rockford, IL). .. Sections were incubated overnight at room temperature with primary antibodies directed against PGP9.5 (rabbit IgG,1:1200, AbD Serotec, Raleigh, NC), CGRP (sheep polyclonal, 1:500, Enzo Life Sciences International, Inc., Plymouth Meeting, PA), langerin (goat polyclonal, 1:100, Santa Cruz Biotechnology Inc., Santa Cruz, CA), |
![a , Cumulative time spent not responding to the tape (no-response time, seconds). b,c , Averaged time courses ± SEM of tape-directed bouts (b) and AUC (c) of CT (n = 8 M/7 F) and PS (n = 9 M/6 F) offspring. d , Ex vivo DRG neuron stimulation and calcium imaging. Percentage (%) of responsive neurons. e-g , Traces of the calcium-induced changes of fluorescence exclusively in responding neurons after addition of capsaicine (e, n = 35 [CT], 21 [PS]), b-alanine (f, n = 97 [CT], 57 [PS]) and MRS2365 (g, n = 87 [CT], 131 [PS]), and amplitude of the neuronal response measured as AUC of the highlighted duration (for 20 s after the addition of the stimulus), normalized per cell (upper panel) or per experiment (lower panel). Each triangle is a responding neuron, and each dot represents an experiment including 2 mice per group (d-g). h-j , Representative confocal microscopy images of neurofilament H (NFH, h) and GDNF Family Receptor Alpha 2 <t>(Gfrα2,</t> i) in glabrous skin sections and filament length (µm, j) per mm 2 in steady state W8 CT (n = 6) and PS (n = 7) offspring. Scale bars, 30 µm (cropped to 7 µm). k,l , Representative confocal microscopy images of Tubβ3, TH, IB4 and Substance P staining (k) and associated percentages (l) among all Tdt + neurons, in DRG from Nav1.8-Cre + ;Tdt CT (n = 6) and PS (n = 6 [TH + ], 7 [IB4 + , SP + ]) at steady state. Scale bars, 200 µm (cropped to 30 µm). Data are from at least two or three independent experiments. Bars represent mean values, and each dot or square corresponds to a single mouse (a,j,l). Mean + SEM; *P < 0.05, **P < 0.01, ***P < 0.001, ns: not significant; Unpaired t-test (a, c), Mann-Whitney test (d-g, j, l), two-sided. Illustrations in d were created using BioRender ( https://biorender.com ).](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_8486/pmc12488486/pmc12488486__41586_2025_9419_Fig7_ESM.jpg)